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Neratinib maleate

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Chemical Structure| 915942-22-2 同义名 : HKI-272 maleate
CAS号 : 915942-22-2
货号 : A165844
分子式 : C34H33ClN6O7
纯度 : 98%
分子量 : 673.115
MDL号 : MFCD30607264
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(371.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Neratinib (HKI-272) maleate is an orally administered, irreversible inhibitor with high selectivity for HER2 and EGFR, exhibiting IC50 values of 59 nM and 92 nM, respectively. This specificity underlines its potential therapeutic application in targeting certain cancers[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.49mL

0.30mL

0.15mL

7.43mL

1.49mL

0.74mL

14.86mL

2.97mL

1.49mL
参考文献

[1]Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64(11), 3958-3965.