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AN2

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Chemical Structure| 7758-73-8 同义名 : LC3-mHTT-IN-AN2
CAS号 : 7758-73-8
货号 : A164604
分子式 : C15H10O4
纯度 : 95%
分子量 : 254.238
MDL号 : MFCD01078551
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(472 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LC3-mHTT-IN-AN2, a linker compound for mHTT-LC3, engages with mutant huntingtin protein (mHTT) and LC3B, but does not interact with wild-type HTT or unrelated control proteins. This compound selectively lowers mHTT levels in cultured neurons from Huntington disease (HD) mice in an allele-specific fashion[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL
参考文献

[1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.