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Indirubin-3′-oxime

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Chemical Structure| 667463-82-3 同义名 : IDR3O;I3O
CAS号 : 667463-82-3
货号 : A164297
分子式 : C16H11N3O2
纯度 : 99%+
分子量 : 277.277
MDL号 : MFCD02683594
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(378.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • JNK1
描述 Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, strongly inhibits cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). It also directly inhibits all three JNK isoforms (JNK1, JNK2, JNK3), with IC50 values of 0.8 μM, 1.4 μM, and 1.0 μM, respectively, and activates Wnt/β-catenin signaling in chondrocytes to promote height growth [1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.61mL

0.72mL

0.36mL

18.03mL

3.61mL

1.80mL

36.07mL

7.21mL

3.61mL
参考文献

[1]Xie Y, et al. Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neurosci Lett. 2004;367(3):355-359.

[2]Hu S, et al. Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. J Mol Neurosci. 2015;57(4):561-570.

[3]Choi S, et al. Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway. Exp Mol Med. 2019;51(9):1-10. Published 2019 Sep 12.