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Cloxiquine

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Chemical Structure| 130-16-5 同义名 : 氯羟喹 ;5-Chloro-8-quinolinol;Dermofungin;NSC35083;Cloxyquin
CAS号 : 130-16-5
货号 : A162839
分子式 : C9H6ClNO
纯度 : 98%
分子量 : 179.603
MDL号 : MFCD00006788
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(584.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cloxiquine (CLQ), a traditional antituberculosic drug, exhibited strong inhibitory effects on the growth and metastasis of melanoma cells both in vivo and in vitro. In contrast, CLQ at the tested doses did not show any apparent toxicity in normal melanocytes and in the liver. At the metabolic level, treatment with CLQ decreased glycolysis, thus potentially inhibiting the "Warburg effect" in B16F10 cells. More importantly, combination of CLQ and 2-deoxyglucose (2-DG), a well-known glycolysis inhibitor, did not show a synergistic effect on the tumor growth and metastasis, indicating that inhibition of glycolysis is potentially involved in mediating CLQ's anti-melanoma function[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.57mL

1.11mL

0.56mL

27.84mL

5.57mL

2.78mL

55.68mL

11.14mL

5.57mL
参考文献

[1]Latosinska JN, Latosinska M, et al. Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by ³⁵Cl NQR, ¹H-¹⁷O and ¹H-¹⁴N NQDR and DFT/QTAIM. J Mol Model. 2011 Jul;17(7):1781-800.

[2]Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S. Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death Dis. 2019;10(6):404. Published 2019 May 28