MRT-14

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Chemical Structure| 1263131-83-4 同义名 : -
CAS号 : 1263131-83-4
货号 : A1603710
分子式 : C24H24N4O5
纯度 : 98%+
分子量 : 448.471
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(234.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MRT-14 is a potent Smo antagonist involved in Hedgehog (Hh) signal transduction and holds potential for researching various cancers linked to abnormal Hh signaling[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.11mL

22.30mL

4.46mL

2.23mL
参考文献

[1]Manetti F, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010;78(4):658-665.