AS-041164

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Chemical Structure| 6318-41-8 同义名 : -
CAS号 : 6318-41-8
货号 : A1603630
分子式 : C11H7NO4S
纯度 : 95%
分子量 : 249.243
MDL号 : N/A
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(481.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AS-041164 is a potent, selective and orally active PI3Kγ isoenzyme inhibitor with an IC50 value of 70 nM. AS-041164 is less active against PI3Kα, PI3Kβ, and PI3Kδ, with IC50 values of 240 nM, 1.45 μM, and 1.70 μM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.06mL

4.01mL

2.01mL

40.12mL

8.02mL

4.01mL
参考文献

[1]Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322(3):923-30.