产品说明书

Sabatolimab

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Chemical Structure| 2252262-24-9 同义名 : MBG453
CAS号 : 2252262-24-9
货号 : A1603393
分子式 : -
纯度 : 95%
分子量 : 0
MDL号 : N/A
存储条件：

粉末 Sealed in dry,under -80°C

液体 -20°C:3-6个月-80°C:24个月
溶解度 : -
动物实验配方：
生物活性
描述

Product Name: Sabatolimab

Corss-reactivity: Human,Cynomolgus

Organism：Human

Target name: TIM-3 / HAVCR2 / CD366

Recommended Dilution Buffer: Sterile PBS or 0.9% saline for reconstitution/dilution. It is recommended to use the reconstituted/diluted product within one month.

Formulation: 100 mM Pro-Ac，20 mM Arg，pH5.0

Endotoxin: < 0.001EU/μg, determined by LAL method.

Purity: >95%. Determined by SDS-PAGE

Purification: Purified, Protein A, affinity column

Storage: -80°C for 2 years under sterile conditions； -20°C for 1 year under sterile conditions； Avoid repeated freeze-thaw cycles.

Isotype: IgG4SP
参考文献

[1]Schwartz S, Patel N, Longmire T, Jayaraman P, Jiang X, Lu H, Baker L, Velez J, Ramesh R, Wavreille AS, Verneret M, Fan H, Hu T, Xu F, Taraszka J, Pelletier M, Miyashiro J, Rinne M, Dranoff G, Sabatos-Peyton C, Cremasco V. Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor. Immunother Adv. 2022 Aug 10;2(1):ltac019. doi: 10.1093/immadv/ltac019. Erratum in: Immunother Adv. 2023 Feb 18;3(1):ltad002. PMID: 36196369; PMCID: PMC9525012.