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YH-306

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Chemical Structure| 1373764-75-0 同义名 : -
CAS号 : 1373764-75-0
货号 : A1601210
分子式 : C19H18N2O2
纯度 : 99%+
分子量 : 306.358
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(58.75 mM)，配合低频超声，并调节pH至1，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 YH-306 is an antitumour drug. YH-306 inhibits colorectal tumour growth and metastasis through the FAK pathway and significantly inhibits migration and invasion of colorectal cancer cells. YH-306 effectively induces apoptosis. YH-306 inhibits the activation of FAK, c-Src, paxillin, and PI3K, Rac1, as well as the expression of MMP2 and MMP9. YH-306 also inhibits actin polymerisation mediated by the actin-related protein (Arp2/3) complex[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.26mL

0.65mL

0.33mL

16.32mL

3.26mL

1.63mL

32.64mL

6.53mL

3.26mL
参考文献

[1]Dai F, et al. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19(2):383-95.