产品说明书

Iruplinalkib

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Chemical Structure| 1854943-32-0 同义名 : WX-0593
CAS号 : 1854943-32-0
货号 : A1601157
分子式 : C29H38ClN6O2P
纯度 : 98%
分子量 : 569.078
MDL号 : MFCD34789645
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 9 mg/mL(15.82 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Iruplinalkib (WX-0593) is a potent, selective, and orally bioavailable inhibitor of ALK and ROS1 tyrosine kinases, displaying favorable safety and promising antitumor efficacy in advanced NSCLC with ALK or ROS1 rearrangements[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.57mL

3.51mL

1.76mL

参考文献

[1]Shi Y, et al. Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial. Signal Transduct Target Ther. 2022;7(1):25.