Tyrosine kinase-IN-7

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Chemical Structure| 345615-74-9 同义名 : -
CAS号 : 345615-74-9
货号 : A1598860
分子式 : C16H15N3OS
纯度 : 95%
分子量 : 297.375
MDL号 : -
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Tyrosine kinase-IN-7 is an inhibitor of the EGFR tyrosine kinase, with IC50s of 0.630 μM against EGFR(WT) and 0.956 μM against EGFR(T790M), displaying anticancer effects on four different cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50 values of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.81mL

3.36mL

1.68mL

33.63mL

6.73mL

3.36mL
参考文献

[1]Elmetwally SA, et al. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. Bioorg Chem. 2019 Jul;88:102944.