产品说明书
Phenacetin
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同义名 : | N-(4-乙氧基苯基)乙酰胺 ;Acetophenetidin;p-Acetophenetidide;NSC 7651;4′-Ethoxyacetanilide |
| CAS号 : | 62-44-2 | |
| 货号 : | A159869 | |
| 分子式 : | C10H13NO2 | |
| 纯度 : | 98% | |
| 分子量 : | 179.22 | |
| MDL号 : | MFCD00009094 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(585.89 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 靶点 |
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| 描述 | Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity[3]. Phenacetin has been linked to renal papillary necrosis in human beings[4]. Since a major portion of a dose of phenacetin is rapidly metabolised to paracetamol, it seems possible that phenacetin owes some of its therapeutic activity to its main metabolite, paracetamol, whereas its most troublesome side effect (methaemoglobinaemia) is due to another metabolite, p-phenetidine[5]. Phenacetin treatment caused considerable nephrotoxicity and hepatotoxicity. Bioisosteric replacement of amide bond by 1,2,3-triazole in the phenacetin moiety yields conjugates with superior efficacy and diminished toxicity[6]. Combination analgesics containing phenacetin increase the risk of development of tumours in the renal pelvis. Phenacetin also increases the risk of development of cancer of the bladder[7]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.58mL 1.12mL 0.56mL |
27.90mL 5.58mL 2.79mL |
55.80mL 11.16mL 5.58mL |
