产品说明书

N-Acetyl-5-hydroxytryptamine

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Chemical Structure| 1210-83-9 同义名 : N-乙酰-5-羟色胺 ;N-Acetylserotonin;Normelatonin;NAS;O-Demethylmelatonin
CAS号 : 1210-83-9
货号 : A158904
分子式 : C12H14N2O2
纯度 : 98%
分子量 : 218.252
MDL号 : MFCD00005656
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(481.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 N-Acetyl-5-hydroxytryptamine (NAS) is the precursor of melatonin, acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-Acetyl-5-hydroxytryptamine activates TrkB receptors in a circadian rhythm and exerts antidepressant effects in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin-independent and MT3 receptor-independent manner[1] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.58mL

0.92mL

0.46mL

22.91mL

4.58mL

2.29mL

45.82mL

9.16mL

4.58mL
参考文献

[1]Jang SW, et al. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3876-81.