产品说明书

Fmoc-Val-Cit-PAB-PNP

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Chemical Structure| 863971-53-3 同义名 : -
CAS号 : 863971-53-3
货号 : A157658
分子式 : C40H42N6O10
纯度 : 98%
分子量 : 766.796
MDL号 : MFCD22200278
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(52.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Fmoc-Val-Cit-PAB-PNP serves as a cleavable linker in antibody-drug conjugate (ADC) synthesis, offering plasma stability on par with non-cleavable linkers[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.30mL

0.26mL

0.13mL

6.52mL

1.30mL

0.65mL

13.04mL

2.61mL

1.30mL
参考文献

[1]Dubowchik GM, et al. Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity. Bioconjug Chem. 2002 Jul-Aug;13(4):855-69.

[2]Yoneda Y, et al. A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1632-6.

[3]Dorywalska M, et al. Effect of attachment site on stability of cleavable antibody drug conjugates. Bioconjug Chem. 2015 Apr 15;26(4):650-9.