产品说明书
(+)-PD 128907 hydrochloride
 |
同义名 : | - |
| CAS号 : | 300576-59-4 | |
| 货号 : | A156825 | |
| 分子式 : | C14H20ClNO3 | |
| 纯度 : | 98% | |
| 分子量 : | 285.767 | |
| MDL号 : | MFCD00210210 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 20 mg/mL(69.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 15 mg/mL(52.49 mM)，配合低频超声助溶 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | The D3 receptor is thought to play a role in reinforcement pathways because it is expressed in high levels within the mesolimbic dopaminergic system and, more specifically, the nucleus accumbens shell. (+)-PD 128907 HCl is a dopaminergic agonist with a range of in vitro D3 selectivity[1]. Low doses of (+)-PD 128907 reduced spontaneous locomotor activity in the rat (ED50 = 13 ± 3 μg/kg, s.c.) a response which was comparable with the non-selective D2,3 receptor agonist apomorphine (ED50 = 13 ± 1.6 μg/kg, s.c.). In addition, (+)-PD 128907 impaired prepulse inhibition of the acoustic startle response, with significant effects observed at doses of 30 μg/kg when appropriate prepulse intensities were used. Higher doses of (+)-PD 128907 HCl reversed gamma-butyrolactone-induced catecholamine synthesis (ED50 = 95 ± 22 and 207 ± 37 μg/kg in accumbens and striatum respectively) and induced yawning (100-300 μg/kg), penile grooming (30-1000 μg/kg) and sniffing (> or = 300 μg/kg). In addition, the observation that (+)-PD 128907 disrupts prepulse inhibition, a phenomenon which is also impaired in schizophrenic subjects[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.50mL 0.70mL 0.35mL |
17.50mL 3.50mL 1.75mL |
34.99mL 7.00mL 3.50mL |
| 参考文献 |
|---|