Clarithromycin

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Chemical Structure| 81103-11-9 同义名 : 克拉红霉素;6氧甲基红霉素;6-0-甲基红霉素A;甲红霉素;甲氧基红霉素;克红霉素 ;A-56268;TE 031;brand name Biaxin.;Abbott-56268;Antibiotic A 56268
CAS号 : 81103-11-9
货号 : A155509
分子式 : C38H69NO13
纯度 : 98%
分子量 : 747.953
MDL号 : MFCD00865140
存储条件：

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(46.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Clarithromycin exhibits a wide range of antimicrobial effects and is known for its capability to inhibit the CYP3A4 enzyme, which catalyzes the alpha-hydroxylation of triazolam, demonstrating an IC50 (Ki) value of 56 (43) µM[1]. This antibiotic also significantly blocks the HERG potassium current in a concentration-dependent manner, with an IC50 of 45.7 µM[2]. Clarithromycin impacts autophagic flux by disrupting the signaling pathway that connects hERG1 and PI3K[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01159574 Multiple Myeloma Phase 2 Active, not recruiting June 2020 United States, New York ... 展开 >> Weill Cornell Medical College New York, New York, United States, 10065 收起 <<
NCT03487562 Healthy Phase 1 Recruiting August 29, 2018 Korea, Republic of ... 展开 >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: In-Jin Jang, MD, PhD    82-2-2072-1666    ijjang@snu.ac.kr    Principal Investigator: In-Jin Jang, MD, PhD 收起 <<
NCT01559935 - Active, not recruiting - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.34mL

0.27mL

0.13mL

6.68mL

1.34mL

0.67mL

13.37mL

2.67mL

1.34mL
参考文献

[1]X J Zhao, et al. An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes. Drug Metab Dispos. 1999 Jul;27(7):776-85.

[2]Scott J C Stanat, et al. Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel. Mol Cell Biochem. 2003 Dec;254(1-2):1-7.

[3]Giulia Petroni, et al. Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K. Cell Death Dis. 2020 Mar 2;11(3):161.

[4]S P Klemens, et al. Activity of clarithromycin against Mycobacterium avium complex infection in beige mice. Antimicrob Agents Chemother. 1992 Nov;36(11):2413-7.