产品说明书
CU-CPT9b
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同义名 : | - |
| CAS号 : | 2162962-69-6 | |
| 货号 : | A155468 | |
| 分子式 : | C16H13NO2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 251.28 | |
| MDL号 : | MFCD31692417 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 85 mg/mL(338.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Endosomal Toll-like receptors (TLR3, TLR7, TLR8, and TLR9) are highly analogous sensors for various viral or bacterial RNA and DNA molecular patterns[2]. CU-CPT9b is a specific TLR8 antagonist, with an IC50 value of 0.7 ± 0.2 nM. It shows high binding affinity towards TLR8 with a Kd of 21 nM. CU-CPT9b is able to suppress TLR8-mediated proinflammatory signaling in various cell lines, human primary cells, and patient specimens[2]. | ||
| 作用机制 | Upon binding to the new site on the protein-protein interface of the TLR8 homodimer, CU-CPT9b stabilizes the preformed TLR8 dimer in its resting state, preventing activation. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.98mL 0.80mL 0.40mL |
19.90mL 3.98mL 1.99mL |
39.80mL 7.96mL 3.98mL |
| 参考文献 |
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