产品说明书

AGN 192870

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Chemical Structure| 166977-57-7 同义名 : -
CAS号 : 166977-57-7
货号 : A1554613
分子式 : C27H22O2
纯度 : 98%
分子量 : 378.462
MDL号 : N/A
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 5 mg/mL(13.21 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 AGN 192870 is a RAR neutral antagonist with Kd values of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. The IC50 values of AGN 192870 for RARα and RARγ are 87 and 32 nM, respectively. AGN 192870 is a partial agonist of RARβ[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.21mL

2.64mL

1.32mL

26.42mL

5.28mL

2.64mL

参考文献

[1]Klein ES, et al. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem. 1996;271(37):22692-22696.