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PARP1-IN-5 dihydrochloride

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Chemical Structure| 2823308-89-8 同义名 : -
CAS号 : 2823308-89-8
货号 : A1554512
分子式 : C25H26Cl2N2O5S
纯度 : 98%
分子量 : 537.455
MDL号 : MFCD34567339
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(223.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(1.86 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 PARP1-IN-5 dihydrochloride is a low-toxicity, orally active, potent, and selective inhibitor of PARP-1, with an IC50 of 14.7 nM. It is applicable for cancer research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.30mL

1.86mL

0.93mL

18.61mL

3.72mL

1.86mL
参考文献

[1]Long H, et al. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. J Med Chem. 2021;64(16):12089-12108.