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BAZ1A-IN-1

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Chemical Structure| 941521-45-5 同义名 : -
CAS号 : 941521-45-5
货号 : A1552503
分子式 : C16H12N4O3S
纯度 : 99%+
分子量 : 340.356
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(73.45 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • bromodomain

    BAZ1A, Kd:0.52 μM
描述 BAZ1A-IN-1 is an effective inhibitor of the bromodomain-containing protein BAZ1A, with a KD value of 0.52 μM against BAZ1A's bromodomain. BAZ1A-IN-1 is highly effective against cancer cell lines that highly express BAZ1A but shows minimal or no effect on cell lines with low BAZ1A expression[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.94mL

0.59mL

0.29mL

14.69mL

2.94mL

1.47mL

29.38mL

5.88mL

2.94mL
参考文献

[1]Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.