产品说明书

	同义名 :	-
	CAS号 :	N/A
	货号 :	A1552284
	分子式 :	C185H273N49O45S6.xC2HF3O2
	纯度 :	98%
	分子量 :	4216.89
	MDL号 :	N/A
	存储条件：	粉末 Sealed in dry,under -80°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

GsMTx4 TFA is a spider venom peptide that specifically inhibits cation-permeable mechanosensitive channels (MSCs) in the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs), reducing astrocyte toxicity and microglial reactivity induced by lysophosphatidylcholine (LPC). GsMTx4 TFA serves as a valuable pharmacological tool for exploring the role of these excitatory MSCs in both normal physiological processes and pathological conditions [1] [2] [4]

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	0.24mL 0.05mL 0.02mL	1.19mL 0.24mL 0.12mL	2.37mL 0.47mL 0.24mL

参考文献

[1]Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45. [2] T M Suchyna, et al. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115(5):583-98. [3] Anna Acheva, et al. Adipokine Leptin Co-operates With Mechanosensitive Ca 2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells. Front Cell Dev Biol. 2021 Jan 6;8:607038. [4] María Velasco-Estevez, et al. Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia. 2020 Feb;68(2):356-375. [5] Medha M Pathak, et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16148-53. [6] Seung Pyo Park, et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain. 2008 Jul;137(1):208-217.