产品说明书

CFT8634

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Chemical Structure| 2704617-96-7 同义名 : -
CAS号 : 2704617-96-7
货号 : A1550899
分子式 : C37H45F3N6O5
纯度 : 98%
分子量 : 710.786
MDL号 : MFCD34662946
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(147.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • BET

    BRD9, DC50:3 nM
描述 CFT8634 is an orally active degrader targeting BRD9, derived from patent WO2021178920A1 compound 174, and is researched for synovial sarcoma and SMARCB1-deleted solid tumors[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.41mL

0.28mL

0.14mL

7.03mL

1.41mL

0.70mL

14.07mL

2.81mL

1.41mL
参考文献

[1]Nasveschuk CG, et, al. Compounds for targeted degradation of brd9. WO2021178920A1.

[2]Brian A, etAl. A Phase 1/2 Study of CFT8634, a Novel Bifunctional Degradation Activating Compound (BIDACmDegrader Of BRD9, in Synovial Sarcoma and SMARCB1-null Tumors.