Sulfamethazine Sodium Salt

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Chemical Structure| 1981-58-4 同义名 : 磺胺二甲嘧啶钠 ;Sulfadimidine sodium;Sulfadimerazine sodium;Sulfadimethyldiazine Sodium Salt;Sulfamethazine sodium
CAS号 : 1981-58-4
货号 : A155058
分子式 : C12H13N4NaO2S
纯度 : 98%
分子量 : 300.31
MDL号 : MFCD00068333
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(832.47 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(332.99 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Sulfamethazine sodium is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg. Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1]. Moreover, a reduction in water intake caused a lower than anticipated dose of sulfamethazine. Under the conditions of the experiment the administration of sulfonamide in drinking water may be an effective means of mass medication of cattle[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.66mL

33.30mL

6.66mL

3.33mL
参考文献

[1]VAN Poucke LSG, VAN Peteghem CH. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994;57(9):796‐801

[2]Church TL, Janzen ED, Sisodia CS, Radostits OM. Blood levels of sulfamethazine achieved in beef calves on medicated drinking water. Can Vet J. 1979;20(2):41‐44