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Miglustat-d9 HCl

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Chemical Structure| 1883545-57-0 同义名 : NB-DNJ-d9;Miglustat-d9;N-Butyldeoxynojirimycin-d9 (hydrochloride);OGT 918-d9 hydrochloride;NB-DNJ-d9 hydrochloride;N-Butyldeoxynojirimycin-d9 hydrochloride;Miglustat-d9 hydrochloride
CAS号 : 1883545-57-0
货号 : A1549691
分子式 : C10H22ClNO4
纯度 : 95% +98%atom%D
分子量 : 264.794
MDL号 : MFCD30182316
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Miglustat-d9 HCl is deuterium-labelled Miglustat HCl. Miglustat HCl is a glucuronide synthase inhibitor used primarily for the treatment of Type I Gaucher disease (GD1)[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.88mL

3.78mL

1.89mL

37.77mL

7.55mL

3.78mL
参考文献

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]Abian, O., et al., Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. Mol Pharm, 2011. 8(6): p. 2390-7.;van Giersbergen, P.L. and J. Dingemanse, Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. J Clin Pharmacol, 2007. 47(10): p. 1277-82.