产品说明书

PF-06648671

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Chemical Structure| 1587727-31-8 同义名 : -
CAS号 : 1587727-31-8
货号 : A1549567
分子式 : C25H23ClF4N4O3
纯度 : 98%+
分子量 : 538.922
MDL号 : MFCD31560371
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PF-06648671 is a novel, brain-penetrable and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40 while increasing Aβ37 and Aβ38 in vitro without inhibiting cleavage of Notch or other substrates[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.28mL

1.86mL

0.93mL

18.56mL

3.71mL

1.86mL
参考文献

[1]Jae Eun Ahn, et al. Pharmacokinetic and Pharmacodynamic Effects of a γ-Secretase Modulator, PF-06648671, on CSF Amyloid-β Peptides in Randomized Phase I Studies. Clin Pharmacol Ther 2020 Jan;107(1):211-220.