产品说明书

E6446

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Chemical Structure| 1219925-73-1 同义名 : -
CAS号 : 1219925-73-1
货号 : A154947
分子式 : C27H35N3O3
纯度 : 99%+
分子量 : 449.585
MDL号 : MFCD28900679
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 E6446 serves as a potent, orally active antagonist of TLR7 and TLR9, employed in studying harmful inflammatory responses. It is also a strong SCD1 inhibitor (KD: 4.61 μM), markedly reducing adipogenic differentiation and hepatic lipogenesis via SCD1-ATF3 signaling. Furthermore, E6446 ameliorates liver pathology in mice fed a high-fat diet (HFD), suggesting its utility in researching non-alcoholic fatty liver disease (NAFLD)[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.12mL

2.22mL

1.11mL

22.24mL

4.45mL

2.22mL
参考文献

[1]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[2]Franklin BS, et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94.

[3]Wang W, et al. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis. Cell Commun Signal. 2023 Sep 30;21(1):268.