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Nur77 modulator 1

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Chemical Structure| 2469975-55-9 同义名 : -
CAS号 : 2469975-55-9
货号 : A1544123
分子式 : C28H25N5O2S
纯度 : 99%+
分子量 : 495.595
MDL号 : -
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(242.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Nur77 modulator 1 exhibits strong binding affinity for Nur77 (KD = 3.58 μM). It enhances Nur77 expression, regulates its sub-cellular localization, triggers Nur77-dependent ER stress and autophagy, ultimately leading to cell apoptosis. It demonstrates anti-hepatoma activity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.09mL

2.02mL

1.01mL

20.18mL

4.04mL

2.02mL
参考文献

[1]Baicun Li, et al. Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. Eur J Med Chem. 2020 Oct 15;204:112608.