产品说明书
FLTX1
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同义名 : | - |
| CAS号 : | 1481401-71-1 | |
| 货号 : | A1544119 | |
| 分子式 : | C31H28N4O4 | |
| 纯度 : | 98% | |
| 分子量 : | 520.578 | |
| MDL号 : | - | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(48.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | FLTX1 is a fluorescent Tamoxifen derivative that specifically labels intracellular Tamoxifen sites (estrogen receptors) under permeabilising and non-permeabilising conditions. FLTX1 possesses the potent anti-estrogenic properties of Tamoxifen in breast cancer cells. FLTX1 has no estrogenic agonistic effect on the uterus [1][2].FLTX1 reduces the proliferation of MCF7 cells in a dose-dependent manner at a concentration range of 0.01-10 μM for 6 days. Pretreating cells with FLTX1 for 24 h, FLTX1 counteracted the E2-induced increase in cell growth to control levels[1][2].At a concentration of 50 μM for 2 hours of action, FLTX1 showed a dose-dependent competition with Tamoxifen in MCF7 cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.92mL 0.38mL 0.19mL |
9.60mL 1.92mL 0.96mL |
19.21mL 3.84mL 1.92mL |
| 参考文献 |
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