产品说明书

NF-κΒ activator 2

Print
Chemical Structure| 2375281-44-8 同义名 : -
CAS号 : 2375281-44-8
货号 : A1543793
分子式 : C16H11FN2O3
纯度 : 99%+
分子量 : 298.269
MDL号 : MFCD34471035
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 250 mg/mL(838.17 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 NF-κΒ activator 2 is a potent and orally active NF-κΒ activator with an EC50 of 1.58 μM. It induces SOD2 by enhancing NF-κΒ expression and activation. NF-κΒ activator 2 is utilized in research on amyotrophic lateral sclerosis (ALS)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.35mL

0.67mL

0.34mL

16.76mL

3.35mL

1.68mL

33.53mL

6.71mL

3.35mL

参考文献

[1]Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.