产品说明书

MLT-943

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Chemical Structure| 1832576-04-1 同义名 : -
CAS号 : 1832576-04-1
货号 : A1539920
分子式 : C16H14ClF3N6O2
纯度 : 98%
分子量 : 414.77
MDL号 : MFCD34368519
存储条件:

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 250 mg/mL(602.74 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 MLT-943 is a potent, selective, and orally active inhibitor of MALT1 protease. It inhibits stimulated IL-2 secretion in PBMC or whole blood with a consistent IC50 across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood). MLT-943 possesses anti-inflammatory properties and is suitable for research on FcγR-mediated inflammation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.05mL

2.41mL

1.21mL

24.11mL

4.82mL

2.41mL

参考文献

[1]Kea Martin, et al. Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology. Front Immunol