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Ziprasidone HCl

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Chemical Structure| 122883-93-6 同义名 : 齐拉西酮盐酸盐 ;CP-88059 hydrochloride;CP-88059;Ziprasidone hydrochloride
CAS号 : 122883-93-6
货号 : A153991
分子式 : C21H22Cl2N4OS
纯度 : 98+%
分子量 : 449.397
MDL号 : MFCD06795476
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • 5-HT

  • Dopamine receptor
描述 Ziprasidone hydrochloride is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity, and is used in the treatment of schizophrenia and bipolar disorder.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01185743 Schizophrenia ... 展开 >> Diabetes 收起 << Phase 4 Completed - Austria ... 展开 >> Medical University of Vienna Vienna, Austria, 1090 收起 <<
NCT00288366 Schizophrenia ... 展开 >> Schizoaffective Disorder Bipolar Disorder 收起 << Not Applicable Completed - United States, Tennessee ... 展开 >> Psychiatric Hospital at Vanderbilt Nashville, Tennessee, United States, 37212 收起 <<
NCT01598324 - Terminated(Clinical trial from... 展开 >> which subjects were recruited closed to enrollment) 收起 << - United States, Massachusetts ... 展开 >> McLean Hospital - McLean Imaging Center Belmont, Massachusetts, United States, 02478 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.13mL

2.23mL

1.11mL

22.25mL

4.45mL

2.23mL
参考文献

[1]Su Z, Chen J, et al. Block of hERG channel by ziprasidone: biophysical properties and molecular determinants. Biochem Pharmacol. 2006 Jan 12;71(3):278-86.

[2]Schmidt AW, Lebel LA, et al. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur J Pharmacol. 2001 Aug 17;425(3):197-201.