Isonicotinic acid

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Chemical Structure| 55-22-1 同义名 : 吡啶-4-甲酸
CAS号 : 55-22-1
货号 : A153232
分子式 : C6H5NO2
纯度 : 97%
分子量 : 123.109
MDL号 : MFCD00006429
存储条件:

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 25 mg/mL(203.07 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Isonicotinic acid, a metabolite of Isoniazid, is produced through hydrazinolysis of Isoniazid, and its conversion can also be catalyzed by cytochrome P450 enzymes such as CYP2C[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.12mL

1.62mL

0.81mL

40.61mL

8.12mL

4.06mL

81.23mL

16.25mL

8.12mL

参考文献

[1]Seng KY, et al. Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers. Antimicrob Agents Chemother. 2015 Nov;59(11):6791-9.