产品说明书

JG-231

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Chemical Structure| 1627126-59-3 同义名 : -
CAS号 : 1627126-59-3
货号 : A1527342
分子式 : C22H18BrCl2N3OS4
纯度 : 98%+
分子量 : 619.468
MDL号 : -
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 2 mg/mL(3.23 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 JG-231, a derivative of JG-98, exhibits anticancer properties by disrupting the Hsp70-BAG3 interaction and impeding the growth of MDA-MB-231 heterograft tumor models in triple-negative breast cancer (TNBC)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.61mL

0.32mL

0.16mL

8.07mL

1.61mL

0.81mL

16.14mL

3.23mL

1.61mL

参考文献

[1]Shao H, et al. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem. 2018 Jul 26;61(14):6163-6177.