产品说明书
GSK3987
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同义名 : | - |
| CAS号 : | 264206-85-1 | |
| 货号 : | A1518329 | |
| 分子式 : | C24H20N2O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 384.427 | |
| MDL号 : | N/A | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(273.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | GSK3987, a broad-spectrum agonist for LXRα/β, exhibits EC50s of 50 nM and 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. This compound enhances ABCA1 and SREBP-1c expression and promotes cellular cholesterol efflux while causing triglyceride accumulation[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.60mL 0.52mL 0.26mL |
13.01mL 2.60mL 1.30mL |
26.01mL 5.20mL 2.60mL |
| 参考文献 |
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[1]HepG2 cells, ABCA1, SREBP-1c, cellular cholesterol, macrophages, triglyceride accumulation |