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MIPS521

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Chemical Structure| 1146188-19-3 同义名 : -
CAS号 : 1146188-19-3
货号 : A1501762
分子式 : C19H10ClF6NOS
纯度 : 95%
分子量 : 449.797
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(55.58 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MIPS521 functions as a positive allosteric modulator of the adenosine A1 receptor (A1AR), with a lower allosteric affinity for A1R (pKB=4.95; KB=11 μM). It demonstrates analgesic effects in vivo by modulating elevated levels of endogenous adenosine [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.12mL

2.22mL

1.11mL

22.23mL

4.45mL

2.22mL
参考文献

[1]Aurelio L, et, al. Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J Med Chem. 2009 Jul 23;52(14):4543-7.

[2]Draper-Joyce CJ, et, al. Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature. 2021 Sep;597(7877):571-576.