产品说明书

CZC-54252 HCl

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Chemical Structure| 1784253-05-9 同义名 : CZC-54252 hydrochloride
CAS号 : 1784253-05-9
货号 : A1500046
分子式 : C22H26Cl2N6O4S
纯度 : 99%+
分子量 : 541.451
MDL号 : MFCD22683847
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(64.64 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CZC-54252 hydrochloride is a potent and selective inhibitor of LRRK2, demonstrating IC50s of 1.28 nM for the wild-type and 1.85 nM for the G2019S mutant form of LRRK2. This compound is particularly effective in reducing G2019S LRRK2-induced human neuronal injury, with an EC50 of approximately 1 nM. CZC-54252 hydrochloride is noted for its neuroprotective activities[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.85mL

0.37mL

0.18mL

9.23mL

1.85mL

0.92mL

18.47mL

3.69mL

1.85mL
参考文献

[1]Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.