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Bemegride

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Chemical Structure| 64-65-3 同义名 : Bemegrid;3-Ethyl-3-methylglutarimide;Zentraleptin;Mikedimide;Malysol;Eukraton;Ahypnon;Agipnon;Antibarbi
CAS号 : 64-65-3
货号 : A149990
分子式 : C8H13NO2
纯度 : 98%
分子量 : 155.194
MDL号 : MFCD00006673
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(193.31 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • GABAA receptor
描述 Bemegride had an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents[3]. The intensity of withdrawal syndrome in rats treated with barbital alone or in combination with the stimulant bemegride or pentylenettrazol was approximately parallel to the degree of related central nervous system depression[4]. The bemegride discriminative stimulus generalized to PTZ (20mg/kg) and was antagonized by chlordiazepoxide (10 mg/kg). Bemegride and cocaine generalized to the PTZ (pentylenetetrazol) discriminative stimulus in a dose-dependent manner, but d-amphetamine, methylphenidate, and nicotine did not[5]. Administration of subconvulsant doses of bemegride results in extensive enhancement of sensory responsiveness to auditory, visual, somatosensory and vibrissa stimulation of neurons in the medullary and mesencephalic reticular formation (RF)[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.44mL

1.29mL

0.64mL

32.22mL

6.44mL

3.22mL

64.44mL

12.89mL

6.44mL
参考文献

[1]Mistry DK, Cottrell GA. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp Physiol. 1990 Mar;75(2):199-209.

[2]Arblaster CI, Cameron DW, et al. Studies on the development of physical dependence on barbitone in the rat and rat atrium. Farmaco Sci. 1986 Jan;41(1):3-22.

[3]Mistry DK, Cottrell GA. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp Physiol. 1990 Mar;75(2):199-209

[4]Arblaster CI, Cameron DW, Laycock GM, Shulman A. Studies on the development of physical dependence on barbitone in the rat and rat atrium. Farmaco Sci. 1986 Jan;41(1):3-22

[5]Shearman G, Lal H. Discriminative stimulus properties of pentylenetetrazol and bemegride: some generalization and antagonism tests. Psychopharmacology (Berl). 1979 Sep;64(3):315-9

[6]Faingold CL, Hoffmann WE. Effects of bemegride on the sensory responses of neurons in the hippocampus and brain stem reticular formation. Electroencephalogr Clin Neurophysiol. 1981 Oct;52(4):316-27