产品说明书

HQ461

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Chemical Structure| 1226443-41-9 同义名 : -
CAS号 : 1226443-41-9
货号 : A1493270
分子式 : C15H15N5OS2
纯度 : 99%+
分子量 : 345.442
MDL号 : MFCD16651741
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(173.69 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 HQ461 is a molecular glue that enhances the interaction between CDK12 and DDB1, leading to the degradation of cyclin K. This degradation disrupts CDK12 activity, reducing phosphorylation of its substrates, downregulating DNA damage response genes, and inducing cell death[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.89mL

0.58mL

0.29mL

14.47mL

2.89mL

1.45mL

28.95mL

5.79mL

2.89mL
参考文献

[1]Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.