PR5-LL-CM01

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Chemical Structure| 1005307-86-7 同义名 : -
CAS号 : 1005307-86-7
货号 : A1483455
分子式 : C23H27N7
纯度 : 98%+
分子量 : 401.507
MDL号 : N/A
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 10 mg/mL(24.91 mM)，配合低频超声，水浴加热至45℃，并调节pH至3，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PR5-LL-CM01 is a potent PRMT5 inhibitor with an IC50 value of 7.5 μM. PR5-LL-CM01 inhibits the proliferation of PDAC cells (PANC1, MiaPaCa2, and AsPC1) with an IC50 value ranging in 2-4 μM. PR5-LL-CM01 inhibits the proliferation of CRC cells (HT29, HCT116, and DLD1) with an IC50 value of 10-11 μM. The IC50 range of PR5-LL-CM01 for CRC cells (HT29, HCT116 and DLD1) is 10-11 μM. PR5-LL-CM01 has higher specific inhibitory efficacy against cancer cells and lower toxicity to normal cells. PR5-LL-CM01 can strongly inhibit the colony forming ability of PANC1 and HT29 cells. PR5-LL-CM01 inhibits the activation of NF-κB and the expression of its target genes in PDAC and CRC cells. At a concentration of less than 15 μM, PR5-LL-CM01 significantly reduced the expression of TNFα and IL8 in PANC1 and HT29 cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.49mL

0.50mL

0.25mL

12.45mL

2.49mL

1.25mL

24.91mL

4.98mL

2.49mL
参考文献

[1]Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8(25):39963-39977.