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L-745870 HCl

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Chemical Structure| 1173023-36-3 同义名 : L-745870 hydrochloride
CAS号 : 1173023-36-3
货号 : A148233
分子式 : C18H20Cl2N4
纯度 : 99%+
分子量 : 363.284
MDL号 : MFCD01529971
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(82.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

0.1 M HCL: 25 mg/mL(68.82 mM)，配合低频超声，并调节pH至3
动物实验配方：
生物活性
描述 L-745870 hydrochloride is a robust, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. It exhibits weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and shows moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.28mL

13.76mL

2.75mL

1.38mL

27.53mL

5.51mL

2.75mL
参考文献

[1]Bristow LJ, et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci. 1997 Jun;18(6):186-8.

[2]Patel S, et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47.

[3]Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.