产品说明书
Tetrahydropapaverine HCl
 |
同义名 : | 去甲劳丹碱盐酸盐 ;Tetrahydropapaverine hydrochloride |
| CAS号 : | 6429-04-5 | |
| 货号 : | A148184 | |
| 分子式 : | C20H26ClNO4 | |
| 纯度 : | 97% | |
| 分子量 : | 379.878 | |
| MDL号 : | MFCD00035267 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(131.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(263.24 mM) |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tetrahydropapaverine is a tryptophan hydroxylase inhibitor with IC50 value of 5.7μM for inactivating tryptophan hydroxylase prepared from the P815 cells, leading to a decrease in serotonin content by the inhibition of tryptophan hydroxylase activity. Tetrahydropapaverine dose-dependently decreased serotonin content at concentration ranging in 5-20μM in P815 cells and inhibitied serotonin content by 42.1% at 5μM post 24h. Tetrahydropapaverine un-competitively inhibited P815-tryptophan hydroxylase with the substrate L-tryptophan, and non-competitively with the cofactor DL-6-methyl-5,6,7,8-tetrahydropteridin. Tetrahydropapaverine exhibited toxic effect on TH-positive neurons and total cells with EC50 value of 180μ and 265μM, respectively. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.63mL 0.53mL 0.26mL |
13.16mL 2.63mL 1.32mL |
26.32mL 5.26mL 2.63mL |
| 参考文献 |
|---|