Tanzisertib
产品说明书
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同义名 : | CC-930 |
| CAS号 : | 899805-25-5 | |
| 货号 : | A148034 | |
| 分子式 : | C21H23F3N6O2 | |
| 纯度 : | 98% | |
| 分子量 : | 448.442 | |
| MDL号 : | MFCD23160040 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(78.05 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 1M HCl: 100 mg/mL(222.99 mM)，配合低频超声，并调节pH至1 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tanzisertib (CC-930) inhibits the formation of phospho-cJun in human PBMC stimulated by phorbol-12-myristate-13-acetate and phytohemeagglutinin with an IC50 value of 1 μM[1]. At concentrations of 1-2 μM, Tanzisertib significantly diminishes hepatocyte apoptosis and necrosis, including in FC-loaded WT hepatocytes[2]. | ||
| 作用机制 | CC-930 inhibits JNK1 and JNK2 in an ATP-competitive manner[3]. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
| Jurkat T cells | Function assay | Inhibition of JNK-mediated GST tagged c-Jun phosphorylation in human Jurkat T cells compound treated for 30 mins prior anisomycin stimulation measured after 40 mins by fluorescence spectrophotometry, IC50=0.2 μM | 22244937 | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.23mL 0.45mL 0.22mL |
11.15mL 2.23mL 1.11mL |
22.30mL 4.46mL 2.23mL |
| 参考文献 |
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