L82-G17

产品说明书

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Chemical Structure| 92285-87-5 同义名 : -
CAS号 : 92285-87-5
货号 : A1476874
分子式 : C11H9ClN4O2
纯度 : 99%+
分子量 : 264.668
MDL号 : N/A
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(453.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 L82-G17 functions as an uncompetitive DNA ligase I (Lig I)-selective inhibitor, hindering phosphodiester bond formation, specifically in the third step of the ligation reaction. It can be utilized as a probe to assess catalytic activity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.89mL

3.78mL

1.89mL

37.78mL

7.56mL

3.78mL
参考文献

[1]Timothy R L Howes, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.