产品说明书
AM-2394
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同义名 : | - |
| CAS号 : | 1442684-77-6 | |
| 货号 : | A147455 | |
| 分子式 : | C22H25N5O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 423.465 | |
| MDL号 : | MFCD30533320 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 30 mg/mL(70.84 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Glucokinase (GK), a member of the hexokinase enzyme family, catalyzes the phosphorylation of glucose to glucose-6-phosphate in the presence of ATP. AM-2394 is a structurally distinct GK activator with an EC50 value of 60 nM, increasing the affinity of GK for glucose by approximately 10-fold. Importantly, AM-2394 exhibited good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability. In an animal model of type 2 diabetes, AM-2394 was administered per os (PO) to male ob/ob mice 30 minutes prior to performing an oral glucose tolerance test (OGTT). Doses of 1, 3, 10, 30 mg/kg reduced glucose excursion, with maximal efficacy seen at 3 mg/kg[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.36mL 0.47mL 0.24mL |
11.81mL 2.36mL 1.18mL |
23.61mL 4.72mL 2.36mL |
| 参考文献 |
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