产品说明书

ON1231320

Print
Chemical Structure| 1312471-39-8 同义名 : 7ao
CAS号 : 1312471-39-8
货号 : A1474056
分子式 : C22H15F2N5O3S
纯度 : 98%
分子量 : 467.448
MDL号 : MFCD28502102
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(106.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ON1231320, a selective inhibitor of PLK2, exhibits an IC50 of 0.31 µM. It impedes the progression of the tumor cell cycle at the G2/M phase during mitosis, leading to apoptosis. As an arylsulfonyl pyrido-pyrimidinone compound, ON1231320 possesses antitumor properties[1][2]. ON1231320 effectively curbs the proliferation of a spectrum of 16 tumor cell lines, including DU145, MCF-7, BT474, SK-OV-3, MIA-PaCa-2, SK-MEL-28, A549, U87, COLO-205, HELA, H1975, RAJI, U205, K562, and GRANTA-519, with IC50 values ranging from 0.035 to 0.2 µM. Additionally, ON1231320 is not known to significantly affect tubulin polymerization[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.70mL

2.14mL

1.07mL

21.39mL

4.28mL

2.14mL
参考文献

[1]M V Ramana Reddy, et al. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem. 2016 Feb 15;24(4):521-44.

[2]Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.