产品说明书

Bimatoprost

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Chemical Structure| 155206-00-1 同义名 : AGN 192024;17-phenyl trinor Prostaglandin F2α ethyl amide;Bimatoprostum;Latisse;Lumigan;17-phenyl trinor PGF2α ethyl amide;15(S)-Bimatoprost
CAS号 : 155206-00-1
货号 : A147258
分子式 : C25H37NO4
纯度 : 98%
分子量 : 415.566
MDL号 : MFCD03411999
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(252.67 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Bimatoprost, a synthetic prostamide F2α analog originally approved for the treatment of ocular hypertension and open-angle glaucoma, is now FDA approved as a 0.03%, solution to be applied once daily to increase eyelashes growth[3]. In March 2020, bimatoprost implant received its first approval, in the USA, for use to reduce intraocular pressure (IOP) in patient with open angle glaucoma or ocular hypertension[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.03mL

2.41mL

1.20mL

24.06mL

4.81mL

2.41mL

参考文献

[1]Sharif NA, Williams GW, Kelly CR. Bimatoprost and its free acid are prostaglandin FP receptor agonists. Eur J Pharmacol. 2001 Dec 7;432(2-3):211-3.

[2]Brubaker RF. Mechanism of action of bimatoprost (Lumigan). Surv Ophthalmol. 2001 May;45 Suppl 4:S347-51.

[3]Barrón-Hernández YL, Tosti A. Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia. Expert Opin Investig Drugs. 2017;26(4):515-522.

[4]Shirley M. Bimatoprost Implant: First Approval [published correction appears in Drugs Aging. 2020 Jul;37(7):549]. Drugs Aging. 2020;37(6):457-462.