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Thalidomide-NH-C2-PEG3-OH

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Chemical Structure| 2140807-23-2 同义名 : -
CAS号 : 2140807-23-2
货号 : A1471098
分子式 : C21H27N3O8
纯度 : 98%
分子量 : 449.454
MDL号 : MFCD32903299
存储条件:

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Thalidomide-NH-C2-PEG3-OH is a conjugate linking an E3 ligase ligand to Thalidomide and a linker, designed for the PROTAC BCL-XL degrader XZ739, based on cereblon ligand[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.12mL

2.22mL

1.11mL

22.25mL

4.45mL

2.22mL

参考文献

[1]Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.