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Chemical Structure| 55224-05-0 同义名 : Erythromycin Cyclocarbonate
CAS号 : 55224-05-0
货号 : A147090
分子式 : C38H65NO14
纯度 : 95%
分子量 : 759.921
MDL号 : MFCD01729176
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(32.9 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Erythromycin Cyclocarbonate, derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms. Erythromycin is used in treatment of respiratory, gastrointestinal, and genital tract infections, as well as skin and soft tissue infections[2]. Compared with other antibiotics, the erythromycins have a good safety record. Considering bioavailability and adverse effect data, a specific brand of enteric-coated erythromycin base tablets is recommended for erythromycin-sensitive infections in adults. For pediatric patients, a liquid formulation of erythromycin estolate or erythromycin ethylsuccinate is recommended[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.32mL

0.26mL

0.13mL

6.58mL

1.32mL

0.66mL

13.16mL

2.63mL

1.32mL
参考文献

[1]Jelić D, Antolović R. From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials. Antibiotics (Basel). 2016 Sep 1;5(3). pii: E29.

[2]Jelić D, Antolović R. From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials. Antibiotics (Basel). 2016;5(3):29. Published 2016 Sep 1

[3]Fraser DG. Selection of an oral erythromycin product. Am J Hosp Pharm. 1980;37(9):1199-1205