产品说明书

MK-8033 HCl

Print
Chemical Structure| 1283000-43-0 同义名 : MK-8033 hydrochloride
CAS号 : 1283000-43-0
货号 : A147035
分子式 : C25H22ClN5O3S
纯度 : 98%
分子量 : 507.992
MDL号 : MFCD28167721
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 5 mg/mL(9.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 7 mg/mL(13.78 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 MK-8033 hydrochloride is an orally active dual inhibitor targeting c-Met and Ron kinases competitively with ATP (IC50s: 1 nM (c-Met),7 nM (Ron)), showing a preference for the activated kinase conformation. MK-8033 hydrochloride is applicable in cancer research, including breast and bladder cancers, as well as non-small cell lung cancers (NSCLCs)[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.84mL

1.97mL

0.98mL

19.69mL

3.94mL

1.97mL
参考文献

[1]Northrup AB, et al, Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated

[2]Bhardwaj V, et al. C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression. J Thorac Oncol. 2012 Aug;7(8):1211-7.

[3]Chandrani Chattopadhyay, et al. Simultaneous inhibition of the HGF/MET and Erk1/2 pathways affect uveal melanoma cell growth and migration. PLoS One. 2014 Feb 13;9(2):e83957.