产品说明书

AXC-715 3HCl

Print
Chemical Structure| 2479276-17-8 同义名 : T785 trihydrochloride;AXC-715 trihydrochloride
CAS号 : 2479276-17-8
货号 : A1469763
分子式 : C18H28Cl3N5
纯度 : 95%
分子量 : 420.807
MDL号 : MFCD34169278
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(285.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AXC-715 (T785) trihydrochloride, a TLR7/TLR8 dual agonist, is derived from patent WO2020168017 A1 [1]. AXC-715 trihydrochloride, also known as compound D from WO2020190734A1, serves for synthesizing antibody-adjuvant immunoconjugates, composed of an antibody construct binding programmed death-ligand 1 (PD-L1) linked to one or more adjuvants [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.88mL

2.38mL

1.19mL

23.76mL

4.75mL

2.38mL
参考文献

[1]Sung-Ju Moon, et al. Compositions containing, methods and uses of antibody-tlr agonist conjugates. Patent WO2020168017A1.

[2]Shelley Erin ACKERMAN, et al. Immunoconjugates targeting pd-l1. Patent WO2020190734A1.