CTB

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Chemical Structure| 451491-47-7 同义名 : -
CAS号 : 451491-47-7
货号 : A1466533
分子式 : C16H13ClF3NO2
纯度 : 99%+
分子量 : 343.728
MDL号 : MFCD02356522
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(305.47 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CTB is a potent activator of the p300 histone acetyltransferase[1]. CTB effectively induces apoptosis in MCF-7 cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.91mL

0.58mL

0.29mL

14.55mL

2.91mL

1.45mL

29.09mL

5.82mL

2.91mL
参考文献

[1]Mantelingu K, et al. Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy. J Phys Chem B. 2007;111(17):4527-4534.

[2]Dastjerdi MN, et al. The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines. Adv Biomed Res. 2013;2:24. Published 2013 Mar 6.

[3]Chen X, et al. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Mol Neurodegener. 2020;15(1):2. Published 2020 Jan 6.